New study reveals how glyphosate in Monsanto’s Roundup inhibits natural detoxification in human cells

Natural News
by Lance Devon

The modern age of industrial agriculture and manufacturing has dumped heavy metals, carninogens, plastics, and pesticides into the environment at alarming rates. These toxins are showing up in most human tissue cells today. One distinct chemical may be trapping these toxins in human cells, limiting the human body’s ability to detoxify its own cells. In a new peer reviewed study, this sinister chemical, glyphosate, has been proven to inhibit the human cell’s ability to detoxify altogether. Glyphosate, found in Monsanto’s Roundup, is being deemed by publishers of the new study “one of the most dangerous chemicals” being unleashed into the environment today.

Download the PDF of the study here.

How glyphosate destroys human cells

Glyphosate, most commonly found in conventional sugar, corn, soy and wheat products, throws off the cytochrome P450 gene pathway, inhibiting enzyme production in the body. CYP enzymes play a crucial role in detoxifying xenobiotics, which include drugs, carcinogens, and pesticides. By inhibiting this natural detoxification process, glyphosate systematically enhances the damaging effects of other environmental toxins that get in the body. This, in turn, disrupts homeostasis, increases inflammation, and leads to a slow deconstruction of the cellular system. Toxins build up in the gut over time and break down through the intestinal walls, infiltrating blood, and ultimately passing through the brain/blood barrier, damaging neurological function.

Important CYP enzymes that are affected include aromatase, the enzyme that converts androgen into estrogen, 21-Hydroxylase, which creates stress hormone cortisol, and aldosterone, which regulates blood pressure.

Getting to the gut

Even as evidence mounts, Monsanto asserts that glyphosate is not harmful to humans, citing that its mechanism of action in plants (the disruption of the shikimate pathway), is not present in humans. This is not true.

The shikimate pathway, which is involved in the synthesis of the essential aromatic amino acids phenylalanine, tyrosine, and tryptophan, is present in human gut bacteria, which has a direct relationship with the human body, aiding in digestion, synthesizing vitamins, detoxifying carcinogens, and participating in immune system function.

By inhibiting the body’s gut flora from performing its essential function in the human body, glyphosate heightens many health issues facing the Western world today.

These conditions include inflammatory bowel diseases, Crohn’s disease, obesity, and even dementia and depression. Also, by restricting gut bacteria from absorbing nutrients, glyphosate voids the body of essential life-giving vitamins.

Depletion of serum tryptophan and its link to obesity

Glysophate’s damaging effects on gut bacteria lead to depleted sulfate supplies in the gut, resulting in inflammatory bowel disease. As more chemicals are absorbed from the environment, alterations in body chemistry actively promote weight gain by blocking nutrient absorption. By effecting CYP enzymes in the liver, obesity incidence is compounded, impairing the body’s ability to detoxify synthetics chemicals. Since serotonin is derived from tryptophan and acts an appetite suppressant, the depletion of tryptophan encourages overeating in the brain, leading to obesity.

In need of urgent, massive awakening

Authors of the new review point out that “glyphosate is likely to be pervasive in our food supply and may be the most biologically disruptive chemical in our environment.” Monsanto is already lashing back at these claims, calling this peer reviewed study, “bad science” and “another bogus study.” What Monsanto fails to is mention that most of the studies on glyphosate’s “safety” are conducted by Monsanto themselves, which is bias to the core.

The authors of this new study instead call out for more independent research to be done to validate their findings. They are concerned with glyphosate’s inhibition of the cytochrome P450 (CYP) enzymes in the body, which are hindering the body’s natural detoxification ability.

There is certainly a need for more empowering education on chemicals like glyphosate. There needs to be a kind of public mass awakening that correlates Monsanto’s Roundup with skull and crossbones. If anything, Americans have the right to know how their food was produced, engineered, and poisoned, and everyone should pitch in and stop using toxic glyphosate-laced Roundup at all costs

Related:   The shikimate pathway as a target for herbicides

New Study Links GMO Food To Leukemia

GreenMedInfo

A new study, yet to receive any media attention, reveals the “leukemogenic” properties of the Bt toxin biopesticides engineered into the vast majority of GMO food crops already within the US food supply.

Last September, the causal link between cancer and genetically modified food was confirmed in a French study, the first independent long-term animal feeding study not commissioned by the biotech corporations themselves. The disturbing details can be found here: New Study Finds GM Corn and Roundup Causes Cancer In Rats

Now, a new study published in the Journal of Hematology & Thromboembolic Diseases indicates that the biopesticides engineered into GM crops known as Bacillus Thuringensis (Bt) or Cry-toxins, may also contribute to blood abnormalities from anemia to hematological malignancies (blood cancers) such as leukemia.

A group of scientists from the Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia/DF, Brazil set out to test the purported human and environmental biosafety of GM crops, looking particularly at the role that the Bt toxin found within virtually all GM food crops plays on non-target or non-insect animal species.

The research was spurred by the Brazilian Collegiate Board of Directors of the National Sanitary Surveillance Agency (ANVISA), who advocated in 2005 for evaluations of toxicity and pathogenicity of microbiological control agents such as Bt toxins, given that little is known about their toxicological potential in non-target organisms, including humans.

While Bacillus Thurigensis spore-crystals have been used since the late 1960’s in agriculture as a foliar insecticide, it was only after the advent of recombinant DNA biotechnology that these toxin-producing genes (known as delta endotoxins) were first inserted into the plants themselves and released into commercial production in the mid-90’s, making their presence in the US food supply and the bodies of exposed populations ubiquitous.

What the new study revealed is that various binary combinations and doses of Bt toxins are capable of targeting mammalian cells, particularly the erythroid (red blood cell) lineage, resulting in red blood cell changes indicative of significant damage, such as anemia. In addition, the study found that Bt toxins suppressed bone marrow proliferation creating abnormal lymphocyte patterns consistent with some types of leukemia.

The researchers also found that one of the prevailing myths about the selective toxicity of Bt to insects, the target species, no longer holds true:

It has been reported that Cry toxins exert their toxicity when activated at alkaline pH of the digestive tract of susceptible larvae, and, because the physiology of the mammalian digestive system does not allow their activation, and no known specific receptors in mammalian intestinal cells have been reported, the toxicity these MCAs to mammals would negligible [8,22,23]. However, our study demonstrated that Bt spore-crystals genetically modified to express individually Cry1Aa, Cry1Ab, Cry1Ac or Cry2A induced hematotoxicity, particularly to the erythroid lineage. This finding corroborates literature that demonstrated that alkali-solubilized Bt spore-crystals caused in vitro hemolysis in cell lines of rat, mouse, sheep, horse, and human erythrocytes and suggested that the plasma membrane of susceptible cells (erythrocytes, in this case) may be the primary target for these toxins.

The study also found:

1) That Cry toxins are capable of exerting their adverse effects when suspended in distilled water, not requiring alkalinization via insect physiology to become activated as formerly believed.

2) That a dose of Cry1Ab as low as 27 mg/kg, their lowest tested dose, was capable of inducing hypochromic anemia in mice – the very toxin has been detected in blood of non-pregnant women, pregnant women and their fetuses in Canada, supposedly exposed through diet.

3) Whereas past reports have found that Bt toxins are generally nontoxic and do not bioaccumulate in fatty tissue or persist in the environment, the new study demonstrated that all Cry toxins tested had a more pronounced effect from 72 hours of exposure onwards, indicating the opposite is true.

4) That high-dose Cry toxin doses caused blood changes indicative of bone marrow damage (damage to “hematopoietic stem cell or bone marrow stroma”).

The authors noted their results “demonstrate leukemogenic activity for other spore-crystals not yet reported in the literature.”

They concluded:

[R]esults showed that the Bt spore-crystals genetically modified to express individually Cry1Aa, Cry1Ab, Cry1Ac or Cry2A can cause some hematological risks to vertebrates, increasing their toxic effects with long-term exposure. Taking into account the increased risk of human and animal exposures to significant levels of these toxins, especially through diet, our results suggest that further studies are required to clarify the mechanism involved in the hematotoxicity found in mice, and to establish the toxicological risks to non-target organisms, especially mammals, before concluding that these microbiological control agents are safe for mammals.

Did you get that? Their conclusion is that it is premature to consider GM toxins to be safe in mammals. Billions have already been exposed to Bt toxins, in combination with glyphosate-based herbicide formulations such as Roundup, and yet, most biotech research scientists and industry regulators still claim they are unequivocally safe. This has much to do with the well-known relationship that biotech corporations like Monsanto have with so-called ‘check book’ science firms who are basically paid to obfuscate adverse health outcomes of their products, such as the GMO-Cancer link. [see: Monsanto-Funded Science Denies Emerging Roundup Cancer Link]

Consider also that the question of combined toxicity of Cry toxins and glyphosate-based residues within plants have not been sufficiently explored, and that glyphosate exposure has already been linked to non-Hodgkins lymphoma and hairy cell leukemia in the biomedical literature.

The reality is that we no longer have time to wait around for additional research to accumulate on the adverse health effects of GMOs, especially considering the biotech industry has far more capital to infuse into their own faux research on the topic.

Some, in fact, argue that we should not be waiting around for the corrupt legislative process to compel manufacturers to label GMOs, rather, we should be fighting to BAN THEM NOW, advocating for the precautionary principle before its too late.

In the meantime, you can join the growing movement to March Against Monsanto, occurring world wide on May 25th, as a way of expressing your desire for real change, as well as vote with your forks, the only immediately effective tool we have against biological and environmental gene-ocide articulated by the dominant GMO-based food system.